Combine single-cell and spatial transcriptomics analysis with MERSCOPE spatial imaging
Explore new dimensions with MERSCOPE, the first high multiplexing, high resolution in situ platform to combine single-cell and spatial genomics analysis powered by MERFISH technology.
- CUSTOM GENE PANELS
- SAMPLE PREPARATION
- SPATIAL IMAGING
- DATA VISUALIZATION
A Complete Spatial Transcriptomics Solution
We integrated MERFISH spatial transcriptomics technology with high resolution spatial imaging, fluidics, image processing, and automation to deliver a complete end-to-end spatial genomics solution. The MERSCOPE® Platform comes with everything your lab needs to get started with spatial imaging. We built our expertise into every component of the system so you can easily obtain and analyze high-quality MERFISH measurements.
The MERSCOPE® Platform is comprised of:
- MERSCOPE Instrument & Analysis Computer
- Intuitive Instrument and Visualization Software
- MERSCOPE Reagents & Consumables
The MERSCOPE® Platform
Position yourself at the forefront of scientific discovery with the MERSCOPE® Platform, the industry’s first high plex, in situ single-cell spatial genomics solution. MERSCOPE uses MERFISH spatial transcriptomics technology to directly map and quantify the spatial distribution of hundreds to tens of thousands of RNA species in individual cells, without the need for downstream sequencing. MERSCOPE is incredibly versatile across applications and sample types, revolutionizing life sciences research.
Profile Large Tissue with Sub-cellular Resolution
Through combinatorial labeling, sequential imaging, and error-robust barcoding, MERFISH technology provides MERSCOPE with the highest detection efficiency and resolution available for spatially profiling the transcriptome, from whole tissue section to single-cell and finally sub-cellular spatial imaging across the whole tissue. We are proud to offer a Data Release Program to provide researchers with public access to MERSCOPE generated spatial genomics data.
MERSCOPE Instrument
MERSCOPE uses MERFISH technology to directly map and quantify the spatial distribution of hundreds to tens of thousands of RNA species in individual cells, without the need for downstream sequencing. The instrument is comprised of an imaging box and a processing computer.
- High Sensitivity: Detect low expressing genes that can be missed using other technologies.
- High Spatial Resolution: Localize RNA transcripts at a sub-cellular level with ≤100 nm resolution.
- Effective Multiplexing Capacity: High multiplexing with custom gene panel design. Current chemistry up to 1000 genes.
- Versatility: Measure your specified genes on many sample or tissue types
- Ease of Use: Intuitive automation and complete reagent packs allow for a walk-away system.
Vizgen® Gene Panel Design Portal
The Vizgen® Gene Panel Portal is a user-friendly web-based application for building custom gene panels to run on the MERSCOPE® Platform. With the Portal you can customize your gene panels with real-time feedback about which genes are most suitable for a MERFISH measurement. The Portal guides you through each step, making the entire process simple and easy.
From the Portal you can:
- Build custom MERFISH gene panels
- Request quotes for gene panels, reagents, and consumables
- Download a panel’s Codebook
- Access previously designed panels and quotes
- Access Vizgen Customer resources
The MERSCOPE Workflow
Vizgen also offers Pre-Defined gene panels panels that are ready for your projects.
MERSCOPE® Vizualizer Software
The MERSCOPE® Vizualizer software enables users to interact, analyze, and interpret even the most complex spatial transcriptomics datasets generated by a MERFISH experiment. Our intuitive software seamlessly combines spatial context at the single-cell level to assist researchers with gaining valuable biological insights. With the tool, you can easily visualize MERFISH data including:
- Imaged cells
- Detected transcripts
- Heat map- 2D cells-genes table
- Scatterplot-displays dimensionality reduced cells and cell clusters
- Generate high-resolution images
Vizgen Post-processing Tool for Cell segmentation
The Vizgen post-processing tool (VPT) uses cell segmentation methods to draw cell boundaries and generates single cell output by combining the results merfishdata. With VPT, users can change methods of cell segmentation to better fit the data for improved single-cell analysis.
Get In Touch With Us
Do you have any questions or enquiry that needs clarification? Contact Us and we will get back to you as soon as possible.